Article
Validation of a multi-omics strategy for prioritizing personalized candidate driver genes
Oncotarget - 21 Jun 2016
Liang Li, Song Liting, Yang Yi, Tian Ling, Li Xiaoyuan, Wu Songfeng, Huang Wenxun, Ren Hong, Tang Ni, Ding Keyue
Abstract excerpt
Significant heterogeneity between different tumors prevents the discovery of cancer driver genes, especially in a patient-specific manner. We previously prioritized five personalized candidate mutation-driver genes in a hyper-mutated hepatocellular carcinoma patient using a multi-omics strategy. However, the roles of the prioritized driver genes and patient-specific mutations in hepatocarcinogenesis are unclear....
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