Article
Identification of a novel metabolic-related mutation (IDH1) in metastatic pancreatic cancer.
Cancer biology & therapy - 3 Apr 2018
Brody Jonathan R, Yabar Cinthya S, Zarei Mahsa, Bender Joseph, Matrisian Lynn M, Rahib Lola, Heartwell Craig, Mason Kimberly, Yeo Charles J, Peiper Stephen C, Jiang Wei, Varieur Katelyn, Madhavan Subha, Petricoin Emanuel, Fortuna Danielle, Curtis Mark, Wang Zi-Xuan, Pishvaian Michael J, Winter Jordan M
Abstract excerpt
Isocitrate dehydrogenase 1 (IDH1) is a metabolic enzyme implicated in cancer cell metabolic reprogramming. This is underscored by the detection of functional, somatic IDH1 mutations frequently found in secondary glioblastoma. To our knowledge, there has never been a reported, validated case of an IDH1 mutation in a pancreatic ductal adenocarcinoma (PDA). Herein, we present a case of a patient with metastatic PDA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.