Article
HIV DNA Set Point is Rapidly Established in Acute HIV Infection and Dramatically Reduced by Early ART.
EBioMedicine - 1 Sept 2016
Ananworanich Jintanat, Chomont Nicolas, Eller Leigh Ann, Kroon Eugene, Tovanabutra Sodsai, Bose Meera, Nau Martin, Fletcher James L K, Tipsuk Somporn, Vandergeeten Claire, O'Connell Robert J, Pinyakorn Suteeraporn, Michael Nelson, Phanuphak Nittaya, Robb Merlin L
Abstract excerpt
HIV DNA is a marker of HIV persistence that predicts HIV progression and remission, but its kinetics in early acute HIV infection (AHI) is poorly understood. We longitudinally measured the frequency of peripheral blood mononuclear cells harboring total and integrated HIV DNA in 19 untreated and 71 treated AHI participants, for whom 50 were in the earliest Fiebig I/II (HIV IgM-) stage, that is ≤2weeks from...
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