Article
Association of miR-146a, miR-149, miR-196a2, and miR-499 Polymorphisms with Ossification of the Posterior Longitudinal Ligament of the Cervical Spine.
PloS one - 1 Jan 2016
Lim Jae Joon, Shin Dong Ah, Jeon Young Joo, Kumar Hemant, Sohn Seil, Min Hyoung Sik, Lee Jang Bo, Kuh Sung Uk, Kim Keung Nyun, Kim Jung Oh, Kim Ok Joon, Ropper Alexander E, Kim Nam Keun, Han In Bo
Abstract excerpt
BACKGROUND: Ossification of the posterior longitudinal ligament (OPLL) of the spine is considered a multifactorial and polygenic disease. We aimed to investigate the association between four single nucleotide polymorphisms (SNPs) of pre-miRNAs [miR-146aC>G (rs2910164), miR-149T>C (rs2292832), miR-196a2T>C (rs11614913), and miR-499A>G (rs3746444)] and the risk of cervical OPLL in the Korean population. METHODS:...
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