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Microfold Cells Actively Translocate Mycobacterium tuberculosis to Initiate Infection

21 Jul 2016

Abstract excerpt

The prevailing paradigm is that tuberculosis infection is initiated when patrolling alveolar macrophages and dendritic cells within the terminal alveolus ingest inhaled Mycobacterium tuberculosis (Mtb). However, definitive data for this model are lacking. Among the epithelial cells of the upper airway, a specialized epithelial cell known as a microfold cell (M cell) overlies various components of...

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PMID: 27452467
DOI: 10.1016/j.celrep.2016.06.080

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