Trafficking of Superinfecting<i>Mycobacterium</i>Organisms into Established Granulomas Occurs in Mammals and Is Independent of the Erp and ESX‐1 Mycobacterial Virulence Loci

Abstract excerpt

Although tuberculous granulomas, which are composed of infected macrophages and other immune cells, have long been considered impermeable structures, recent studies have shown that superinfecting Mycobacterium marinum traffic rapidly to established fish and frog granulomas by host-mediated and Mycobacterium-directed mechanisms. The present study shows that superinfecting Mycobacterium tuberculosis and...

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