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Article

Metabolic modelling reveals the specialization of secondary replicons for niche adaptation in Sinorhizobium meliloti.

Nature communications - 22 Jul 2016

diCenzo George C, Checcucci Alice, Bazzicalupo Marco, Mengoni Alessio, Viti Carlo, Dziewit Lukasz, Finan Turlough M, Galardini Marco, Fondi Marco

Abstract excerpt

The genome of about 10% of bacterial species is divided among two or more large chromosome-sized replicons. The contribution of each replicon to the microbial life cycle (for example, environmental adaptations and/or niche switching) remains unclear. Here we report a genome-scale metabolic model of the legume symbiont Sinorhizobium meliloti that is integrated with carbon utilization data for 1,500 genes with 192...

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Identifiers

PMID: 27447951
DOI: 10.1038/ncomms12219
PMCID: PMC4961836

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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