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Article

Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma.

Proceedings of the National Academy of Sciences of the United States of America - 2 Aug 2016

Metz Heather E, Kargl Julia, Busch Stephanie E, Kim Kyoung-Hee, Kurland Brenda F, Abberbock Shira R, Randolph-Habecker Julie, Knoblaugh Sue E, Kolls Jay K, White Morris F, Houghton A McGarry

Abstract excerpt

Insulin receptor substrate-1 (IRS-1) is a signaling adaptor protein that interfaces with many pathways activated in lung cancer. It has been assumed that IRS-1 promotes tumor growth through its ability to activate PI3K signaling downstream of the insulin-like growth factor receptor. Surprisingly, tumors with reduced IRS-1 staining in a human lung adenocarcinoma tissue microarray displayed a significant survival...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27439864
DOI: 10.1073/pnas.1601989113
PMCID: PMC4978299

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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