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Article

Genetics versus environment in the pathophysiology of sagittal synostosis.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery - 18 Jul 2026

De Gregorio Valentina, Tosi Domiziano D, Vita Alessia, Salvati Martina, Massimi Luca, Tamburrini Gianpiero, Tiberio Federica, Lattanzi Wanda

Abstract excerpt

PURPOSE: This systematic review aims to provide an updated overview of the relative contribution of germline genetic and environmental factors to the pathophysiology of sagittal craniosynostosis (sCS). METHODS: Using the PubMed database in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, relevant studies addressing genetic and/or environmental determinants of...

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Craniosynostoses
Environment
Gene-Environment Interaction
Genetic Predisposition to Disease

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PMID: 42470489
DOI: 10.1007/s00381-026-07396-5
PMCID: PMC13380559

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