Article
Mitochondrial tRNA mutations may be infrequent in hepatocellular carcinoma patients.
Genetics and molecular research : GMR - 24 Jun 2016
Li G, Duan Y X, Zhang X B, Wu F
Abstract excerpt
Mitochondrial DNA mutations have been shown to play important roles in the pathogenesis of hepatocellular carcinoma (HCC). In particular, genes encoding mitochondrial tRNA (mt-tRNA) are hotspots for pathogenic mutations associated with HCC. Recently, an increasing number of studies have reported the involvement of such mutations in this disease. As a result, several mt-tRNA mutations associated with HCC have been...
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