Article
Mitochondrial tRNAThr 15891C>G mutation was not associated with Leber's hereditary optic neuropathy in Han Chinese patients.
Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis - 1 Jan 2016
Jiang Zhaochang, Yu Jinfang, Xia Bohou, Zhuo Guangchao
Abstract excerpt
Mutations in mitochondrial DNA (mtDNA) were the most important causes of Leber's hereditary optic neuropathy (LHON). To date, approximately 25 LHON-associated mtDNA mutations have been identified in various ethnic populations. Three primary mutations, the 3460G > A, 11778G > A and 14484T > C, in genes encoding the subunits of respiratory chain complex I, were the most common LHON-associated mtDNA mutations....
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