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Huntington's disease: nearly four decades of human molecular genetics.

Human molecular genetics - 1 Oct 2021

Gusella James F, Lee Jong-Min, MacDonald Marcy E

Abstract excerpt

Huntington's disease (HD) is a devastating neurogenetic disorder whose familial nature and progressive course were first described in the 19th century but for which no disease-modifying treatment is yet available. Through the active participation of HD families, this disorder has acted as a flagship for the application of human molecular genetic strategies to identify disease genes, understand pathogenesis and...

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Identifiers

PMID: 34169318
DOI: 10.1093/hmg/ddab170
PMCID: PMC8490011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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