Article
Splenomegaly, elevated alkaline phosphatase and mutations in the SRSF2/ASXL1/RUNX1 gene panel are strong adverse prognostic markers in patients with systemic mastocytosis.
Leukemia - 1 Dec 2016
Jawhar M, Schwaab J, Hausmann D, Clemens J, Naumann N, Henzler T, Horny H-P, Sotlar K, Schoenberg S O, Cross N C P, Fabarius A, Hofmann W-K, Valent P, Metzgeroth G, Reiter A
Abstract excerpt
We evaluated the impact of clinical and molecular characteristics on overall survival (OS) in 108 patients with indolent (n=41) and advanced systemic mastocytosis (SM) (advSM, n=67). Organomegaly was measured by magnetic resonance imaging-based volumetry of the liver and spleen. In multivariate analysis of all patients, an increased spleen volume ⩾450 ml (hazard ratio (HR), 5.2; 95% confidence interval (CI),...
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