Article
Evaluation of low-template DNA profiles using peak heights.
Statistical applications in genetics and molecular biology - 1 Oct 2016
Steele Christopher D, Greenhalgh Matthew, Balding David J
Abstract excerpt
In recent years statistical models for the analysis of complex (low-template and/or mixed) DNA profiles have moved from using only presence/absence information about allelic peaks in an electropherogram, to quantitative use of peak heights. This is challenging because peak heights are very variable and affected by a number of factors. We present a new peak-height model with important novel features, including...
Topics
- Algorithms
- Alleles
- Computer Simulation
- DNA
- DNA Fingerprinting
- Forensic Genetics
- Genetic Linkage
- Humans
- Likelihood Functions
- Models, Genetic
- Models, Statistical