Article
Common variants in IL-17A/IL-17RA axis contribute to predisposition to and progression of congestive heart failure.
Medicine - 1 Jul 2016
Sandip Chaugai, Tan Lun, Huang Jin, Li Qing, Ni Li, Cianflone Katherine, Wang Dao Wen
Abstract excerpt
Heart failure is characterized by immune activation leading to production and release of proinflammatory cytokines. Interleukin 17A (IL-17A) is a proinflammatory cytokine and multiple lines of evidence from animal and human studies suggest crucial roles of IL-17A in heart failure. Therefore, we investigated whether common polymorphisms of genes IL17A and IL17RA (coding interleukin 17 receptor A) contribute to...
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