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Article

FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia.

Oncotarget - 2 Aug 2016

Català Albert, Pastor-Anglada Marçal, Caviedes-Cárdenas Liska, Malatesta Roberta, Rives Susana, Vega-García Nerea, Camós Mireia, Fernández-Calotti Paula

Abstract excerpt

FLT3 abnormalities are negative prognostic markers in acute leukemia. Infant leukemias are a subgroup with frequent MLL (KMT2A) rearrangements, FLT3 overexpression and high sensitivity to cytarabine, but dismal prognosis. Cytarabine is transported into cells by Human Equilibrative Nucleoside Transporter-1 (hENT1, SLC29A1), but the mechanisms that regulate hENT1 in acute leukemia have been scarcely studied.We...

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Share to Cytarabine
Share to fms-Like Tyrosine Kinase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Histone-Lysine N-Methyltransferase

Share to Myeloid-Lymphoid Leukemia Protein

Share to Nucleoside Transport Proteins

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Source

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Identifiers

PMID: 27391351
DOI: 10.18632/oncotarget.10448
PMCID: PMC5226548

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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