Article
Smac mimetic LCL161 supports neuroblastoma chemotherapy in a drug class-dependent manner and synergistically interacts with ALK inhibitor TAE684 in cells with ALK mutation F1174L.
Oncotarget - 8 Nov 2016
Najem Safiullah, Langemann Doerte, Appl Birgit, Trochimiuk Magdalena, Hundsdoerfer Patrick, Reinshagen Konrad, Eschenburg Georg
Abstract excerpt
Neuroblastoma is the most common extracranial solid tumor during infancy and childhood.Outcome of high-risk and late-stage disease remains poor despite intensive treatment regimens.Suppressing inhibitor of apoptosis proteins (IAPs) using Smac mimetics (SM) significantly sensitizes neuroblastoma (NB) cells for chemotherapy, however strongly dependent on the cytotoxic drug combined with SM.Therefore, a systematic...
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