Article
Temperate phages both mediate and drive adaptive evolution in pathogen biofilms.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 2016
Davies Emily V, James Chloe E, Williams David, O'Brien Siobhan, Fothergill Joanne L, Haldenby Sam, Paterson Steve, Winstanley Craig, Brockhurst Michael A
Abstract excerpt
Temperate phages drive genomic diversification in bacterial pathogens. Phage-derived sequences are more common in pathogenic than nonpathogenic taxa and are associated with changes in pathogen virulence. High abundance and mobilization of temperate phages within hosts suggests that temperate phages could promote within-host evolution of bacterial pathogens. However, their role in pathogen evolution has not been...
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