Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A systemic evolutionary approach to cancer: Hepatocarcinogenesis as a paradigm.

Medical hypotheses - 1 Aug 2016

Mazzocca Antonio, Ferraro Giovanni, Misciagna Giovanni, Carr Brian I

Abstract excerpt

The systemic evolutionary theory of cancer pathogenesis posits that cancer is generated by the de-emergence of the eukaryotic cell system and by the re-emergence of its archaea (genetic material and cytoplasm) and prokaryotic (mitochondria) subsystems with an uncoordinated behavior. This decreased coordination can be caused by a change in the organization of the eukaryote environment (mainly chronic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Carcinoma, Hepatocellular
Share to Fibrosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycolysis

Share to Liver Neoplasms

Share to Models, Theoretical

Share to Systems Biology

Share to Thermodynamics

Source

Identifiers

PMID: 27372872
DOI: 10.1016/j.mehy.2016.05.027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A systemic evolutionary approach to cancer: Hepatocarcinogenesis as a paradigm.PMID 27372872Read ↗

Mitochondria and the evolutionary roots of cancer.Semantic proximity Read ↗

Cancer Etiology: A Metabolic Disease Originating from Life’s Major Evolutionary Transition?Semantic proximity Read ↗

The Eco-Evolutionary Ground State Theory of Cancer and Why Cancer DevelopsSemantic proximity Read ↗

Bioenergetics of life, disease and death phenomena.Semantic proximity Read ↗

Evolutionary Origins of Metabolic Reprogramming in Cancer.Semantic proximity Read ↗

The 21st century hepatologist and a systems biology based approach to liver diseases.Semantic proximity Read ↗

From Oncological Paradigms to Non-Communicable Disease Pandemic. The Need of Recovery Human Biology EvolutionSemantic proximity Read ↗

Evolution of Energy Metabolism, Stem Cells and Cancer Stem Cells: How the Warburg and Barker Hypotheses Might Be LinkedSemantic proximity Read ↗

Ecology meets cancer biology: the cancer swamp promotes the lethal cancer phenotype.Semantic proximity Read ↗

Tumor malignancy is engaged to prokaryotic homolog toolbox.Semantic proximity Read ↗

Cancer may be a pathway to cell survival under persistent hypoxia and elevated ROS: A model for solid‐cancer initiation and early developmentSemantic proximity Read ↗

Relevance of mitochondrial genetics and metabolism in cancer development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.