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Article

Tumor malignancy is engaged to prokaryotic homolog toolbox.

Medical hypotheses - 1 Apr 2012

Fernandes Janaina, Guedes Patrícia G, Lage Celso Luiz S, Rodrigues Juliany Cola F, Lage Claudia de Alencar S

Abstract excerpt

Cancer cells display high proliferation rates and survival provided by high glycolysis, chemoresistance and radioresistance, metabolic features that appear to be activated with malignancy, and seemed to have arisen as early in evolution as in unicellular/prokaryotic organisms. Based on these assumptions, we hypothesize that aggressive phenotypes found in malignant cells may be related to acquired unicellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22285198
DOI: 10.1016/j.mehy.2011.12.014

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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