Article
Type IV pili promote early biofilm formation by Clostridium difficile.
Pathogens and disease - 1 Aug 2016
Maldarelli Grace A, Piepenbrink Kurt H, Scott Alison J, Freiberg Jeffrey A, Song Yang, Achermann Yvonne, Ernst Robert K, Shirtliff Mark E, Sundberg Eric J, Donnenberg Michael S, von Rosenvinge Erik C
Abstract excerpt
Increasing morbidity and mortality from Clostridium difficile infection (CDI) present an enormous challenge to healthcare systems. Clostridium difficile express type IV pili (T4P), but their function remains unclear. Many chronic and recurrent bacterial infections result from biofilms, surface-associated bacterial communities embedded in an extracellular matrix. CDI may be biofilm mediated; T4P are important for...
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