Dissection of the Major Hematopoietic Quantitative Trait Locus in Chromosome 6q23.3 Identifies miR-3662 as a Player in Hematopoiesis and Acute Myeloid Leukemia.

doi:10.1158/2159-8290.CD-16-0023

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Dissection of the Major Hematopoietic Quantitative Trait Locus in Chromosome 6q23.3 Identifies miR-3662 as a Player in Hematopoiesis and Acute Myeloid Leukemia.

Cancer discovery - 1 Sept 2016

Maharry Sophia E, Walker Christopher J, Liyanarachchi Sandya, Mehta Sujay, Patel Mitra, Bainazar Maryam A, Huang Xiaomeng, Lankenau Malori A, Hoag Kevin W, Ranganathan Parvathi, Garzon Ramiro, Blachly James S, Guttridge Denis C, Bloomfield Clara D, de la Chapelle Albert, Eisfeld Ann-Kathrin

Abstract excerpt

UNLABELLED: Chromosomal aberrations and multiple genome-wide association studies (GWAS) have established a major hematopoietic quantitative trait locus in chromosome 6q23.3. The locus comprises an active enhancer region, in which some of the associated SNPs alter transcription factor binding. We now identify miR-3662 as a new functional driver contributing to the associated phenotypes. The GWAS SNPs are strongly...

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PMID: 27354268
DOI: 10.1158/2159-8290.CD-16-0023
PMCID: PMC5168803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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