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LRRC56 deletion causes primary ciliary dyskinesia in mice characterized by dynein arms defects

5 Feb 2025

Abstract excerpt

Leucine Rich Repeat Containing protein 56 (LRRC56), also known as DNAAF12, is a member of the LRRC superfamily, whose dysfunction is associated with mucociliary clearance and laterality defects in humans. Here, we generated LRRC56-knockout mice using the CRISPR/Cas9 nuclease system to specifically target exons 4-5 of the LRRC56 gene. We observed that homozygous LRRC56 gene deletion is definitely deleterious, as...

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PMID: 39912490
DOI: 10.1242/bio.061846

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