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TNFα Impairs Rhabdoviral Clearance by Inhibiting the Host Autophagic Antiviral Response

28 Jun 2016

Abstract excerpt

TNFα is a pleiotropic pro-inflammatory cytokine with a key role in the activation of the immune system to fight viral infections. Despite its antiviral role, a few viruses might utilize the host produced TNFα to their benefit. Some recent reports have shown that anti-TNFα therapies could be utilized to treat certain viral infections. However, the underlying mechanisms by which TNFα can favor virus replication...

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PMID: 27351838
DOI: 10.1371/journal.ppat.1005699

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