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Article

Generation of induced pluripotent stem cells (iPSCs) from a Bernard-Soulier syndrome patient carrying a W71R mutation in the GPIX gene.

Stem cell research - 1 May 2016

Lopez-Onieva Lourdes, Montes Rosa, Lamolda Mar, Romero Tamara, Ayllon Verónica, Lozano Maria Luisa, Vicente Vicente, Rivera José, Ramos-Mejía Verónica, Real Pedro J

Abstract excerpt

We generated an induced pluripotent stem cell (iPSC) line from a Bernard-Soulier Syndrome (BSS) patient carrying the mutation p.Trp71Arg in the GPIX locus (BSS1-PBMC-iPS4F4). Peripheral blood mononuclear cells (PBMCs) were reprogrammed using heat sensitive non-integrative Sendai viruses containing the reprogramming factors Oct3/4, SOX2, KLF4 and c-MYC. Successful silencing of the exogenous reprogramming factors...

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Source

Identifiers

PMID: 27346198
DOI: 10.1016/j.scr.2016.04.013

Genes

KLF4
MYC
SOX2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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