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Article

Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H266.

Stem cell research - 1 Jan 2016

Marthaler Adele G, Tubsuwan Alisa, Schmid Benjamin, Poulsen Ulla B, Engelbrecht Alexander F, Mau-Holzmann Ulrike A, Hyttel Poul, Nielsen Troels T, Nielsen Jørgen E, Holst Bjørn

Abstract excerpt

Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disease primarily affecting the cerebellum. Very little is known about the molecular mechanisms underlying the disease and, to date, no cure or treatment is available. We have successfully generated bona fide induced pluripotent stem cell (iPSC) lines of SCA2 patients in order to study a disease-specific phenotype. Here, we demonstrate the gene...

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Source

Identifiers

PMID: 27345815
DOI: 10.1016/j.scr.2015.12.048

Genes

ATXN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H266.PMID 27345815Read ↗

Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H196.Semantic proximity Read ↗

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