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Article

Generation of spinocerebellar ataxia type 2 patient-derived iPSC line H271.

Stem cell research - 1 Jan 2016

Marthaler Adele G, Tubsuwan Alisa, Schmid Benjamin, Poulsen Ulla B, Hyttel Poul, Nielsen Jørgen E, Nielsen Troels T, Holst Bjørn

Abstract excerpt

Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disease primarily affecting the cerebellum. Very little is known about the molecular mechanisms underlying the disease and, to date, no cure or treatment is available. Here, we demonstrate the generation of an induced pluripotent stem cell (iPSC) line of a SCA2 patient. The selected clone has been proven to be a bona fide iPSC line, which retains a...

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PMID: 27345803
DOI: 10.1016/j.scr.2015.12.027

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