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Article

The Promise of Epigenomic Therapeutics in Pancreatic Cancer

1 Jun 2016

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is often viewed to arise primarily by genetic alterations. However, today we know that many aspects of the cancer phenotype require a crosstalk among these genetic alterations with epigenetic changes. Indeed, aberrant gene expression patterns, driven by epigenetics are fixed by altered signaling from mutated oncogenes and tumor suppressors to define the PDAC phenotype. This...

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PMID: 27337224
DOI: 10.2217/epi-2015-0016

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