Article
Apoptosis-Resistant Cardiac Progenitor Cells Modified With Apurinic/Apyrimidinic Endonuclease/Redox Factor 1 Gene Overexpression Regulate Cardiac Repair After Myocardial Infarction.
Stem cells translational medicine - 1 Aug 2016
Aonuma Tatsuya, Takehara Naofumi, Maruyama Keisuke, Kabara Maki, Matsuki Motoki, Yamauchi Atsushi, Kawabe Jun-Ichi, Hasebe Naoyuki
Abstract excerpt
UNLABELLED: : Overcoming the insufficient survival of cell grafts is an essential objective in cell-based therapy. Apurinic/apyrimidinic endonuclease/redox factor 1 (APE1) promotes cell survival and may enhance the therapeutic effect of engrafted cells. The aim of this study is to determine whether APE1 overexpression in cardiac progenitor cells (CPCs) could ameliorate the efficiency of cell-based therapy. CPCs...
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