Article
Distribution of MEFV gene mutations and R202Q polymorphism in the Serbian population and their influence on oxidative stress and clinical manifestations of inflammation.
Pediatric rheumatology online journal - 1 Jul 2016
Milenković Jelena, Vojinović Jelena, Debeljak Maruša, Toplak Nataša, Lazarević Dragana, Avčin Tadej, Jevtović-Stoimenov Tatjana, Pavlović Dušica, Bojanić Vladmila, Milojković Maja, Kocić Gordana, Veljković Andrej
Abstract excerpt
BACKGROUND: The Mediterranean fever (MEFV) gene codes for protein pyrin, one of the regulators of inflammasome activity in innate immune cells. Mutations in this gene are considered the primary cause of Familial Mediterranean fever, but are also found in other monogenic and multifactorial autoinflammatory diseases. The aim of the study was to determine if healthy carriers of MEFV gene mutations and R202Q...
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