Article
A novel core genome-encoded superantigen contributes to lethality of community-associated MRSA necrotizing pneumonia.
PLoS pathogens - 1 Oct 2011
Wilson Gillian J, Seo Keun Seok, Cartwright Robyn A, Connelley Timothy, Chuang-Smith Olivia N, Merriman Joseph A, Guinane Caitriona M, Park Joo Youn, Bohach Gregory A, Schlievert Patrick M, Morrison W Ivan, Fitzgerald J Ross
Abstract excerpt
Bacterial superantigens (SAg) stimulate T-cell hyper-activation resulting in immune modulation and severe systemic illnesses such as Staphylococcus aureus toxic shock syndrome. However, all known S. aureus SAgs are encoded by mobile genetic elements and are made by only a proportion of strains. Here, we report the discovery of a novel SAg staphylococcal enterotoxin-like toxin X (SElX) encoded in the core genome...
Topics
- Animals
- Cattle
- Community-Acquired Infections
- Enterotoxins
- Evolution, Molecular
- Genetic Variation
- Humans
- Interspersed Repetitive Sequences
- Methicillin-Resistant Staphylococcus aureus