Article
Genotypic Diversity of Staphylococcus aureus α-Hemolysin Gene (hla) and Its Association with Clonal Background: Implications for Vaccine Development.
PloS one - 1 Jan 2016
Xiao Meng, Zhao Rui, Zhang Qi, Fan Xin, O'Sullivan Matthew V N, Li Dong-Fang, Wang Xin-Ying, Wu Hong-Long, Kong Fanrong, Xu Ying-Chun
Abstract excerpt
The α-hemolysin, encoded by the hla gene, is a major virulence factor in S. aureus infections. Changes in key amino acid residues of α-hemolysin can result in reduction, or even loss, of toxicity. The aim of this study was to investigate the diversity of the hla gene sequence and the relationship of hla variants to the clonal background of S. aureus isolates. A total of 47 clinical isolates from China were used...
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