Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The embryological basis of subclinical hypertrophic cardiomyopathy.

Scientific reports - 21 Jun 2016

Captur Gabriella, Ho Carolyn Y, Schlossarek Saskia, Kerwin Janet, Mirabel Mariana, Wilson Robert, Rosmini Stefania, Obianyo Chinwe, Reant Patricia, Bassett Paul, Cook Andrew C, Lindsay Susan, McKenna William J, Mills Kevin, Elliott Perry M, Mohun Timothy J, Carrier Lucie, Moon James C

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomeric proteins, the commonest being MYBPC3 encoding myosin-binding protein C. It is characterised by left ventricular hypertrophy but there is an important pre-hypertrophic phenotype with features including crypts, abnormal mitral leaflets and trabeculae. We investigated these during mouse cardiac development using high-resolution episcopic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy, Hypertrophic
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Genotype

Share to Hypertrophy, Left Ventricular

Share to Mitral Valve

Source

Open in PubMed Open full text

Identifiers

PMID: 27323879
DOI: 10.1038/srep27714
PMCID: PMC4914973

Genes

MYBPC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The embryological basis of subclinical hypertrophic cardiomyopathy.PMID 27323879Read ↗

Abnormal ventricular wall patterning precedes and drives MYBPC3 hypertrophic cardiomyopathySemantic proximity Read ↗

Prevalence and clinical profile of myocardial crypts in hypertrophic cardiomyopathy.Semantic proximity Read ↗

Myoarchitectural disarray of hypertrophic cardiomyopathy begins pre‐birthSemantic proximity Read ↗

Multiple myocardial crypts on modified long-axis view are a specific finding in pre-hypertrophic HCM mutation carriers.Semantic proximity Read ↗

Cardiac myosin binding protein C regulates postnatal myocyte cytokinesisSemantic proximity Read ↗

Structural abnormalities of the inferoseptal left ventricular wall detected by cardiac magnetic resonance imaging in carriers of hypertrophic cardiomyopathy mutations.Semantic proximity Read ↗

Imaging heart development using high-resolution episcopic microscopySemantic proximity Read ↗

Molecular mechanism of ventricular trabeculation/compaction and the pathogenesis of the left ventricular noncompaction cardiomyopathy (LVNC).Semantic proximity Read ↗

Notch signalling in ventricular chamber development and cardiomyopathySemantic proximity Read ↗

14-3-3ε Plays a Role in Cardiac Ventricular Compaction by Regulating the Cardiomyocyte Cell CycleSemantic proximity Read ↗

Images in cardiovascular medicine. Prominent crypt formation in the inferoseptum of a hypertrophic cardiomyopathy mutation carrier mimics noncompaction cardiomyopathy.Semantic proximity Read ↗

Prediction of sarcomere mutations in subclinical hypertrophic cardiomyopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.