Article
Prediction of sarcomere mutations in subclinical hypertrophic cardiomyopathy.
Circulation. Cardiovascular imaging - 1 Nov 2014
Captur Gabriella, Lopes Luis R, Mohun Timothy J, Patel Vimal, Li Chunming, Bassett Paul, Finocchiaro Gherardo, Ferreira Vanessa M, Esteban Maite Tome, Muthurangu Vivek, Sherrid Mark V, Day Sharlene M, Canter Charles E, McKenna William J, Seidman Christine E, Bluemke David A, Elliott Perry M, Ho Carolyn Y, Moon James C
Abstract excerpt
BACKGROUND: Sarcomere protein mutations in hypertrophic cardiomyopathy induce subtle cardiac structural changes before the development of left ventricular hypertrophy (LVH). We have proposed that myocardial crypts are part of this phenotype and independently associated with the presence of sarcomere gene mutations. We tested this hypothesis in genetic hypertrophic cardiomyopathy pre-LVH (genotype positive, LVH...
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