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Article

Repetitive element hypermethylation in multiple sclerosis patients

17 Jun 2016

Abstract excerpt

BACKGROUND: Multiple sclerosis (MS) is a complex disorder of the central nervous system whose cause is currently unknown. Evidence is increasing that DNA methylation alterations could be involved in inflammatory and neurodegenerative diseases and could contribute to MS pathogenesis. Repetitive elements Alu, LINE-1 and SAT-α, are widely known as estimators of global DNA methylation. We investigated Alu, LINE-1 and...

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PMID: 27317098
DOI: 10.1186/s12863-016-0395-0

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