Article
MARCH2 regulates autophagy by promoting CFTR ubiquitination and degradation and PIK3CA-AKT-MTOR signaling.
Autophagy - 1 Sept 2016
Xia Dan, Qu Liujing, Li Ge, Hongdu Beiqi, Xu Chentong, Lin Xin, Lou Yaxin, He Qihua, Ma Dalong, Chen Yingyu
Abstract excerpt
MARCH2 (membrane-associated RING-CH protein 2), an E3 ubiquitin ligase, is mainly associated with the vesicle trafficking. In the present study, for the first time, we demonstrated that MARCH2 negatively regulates autophagy. Our data indicated that overexpression of MARCH2 impaired autophagy, as evidenced by attenuated levels of LC3B-II and impaired degradation of endogenous and exogenous autophagic substrates....
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