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Article

Chloroquine anticancer activity is mediated by autophagy-independent effects on the tumor vasculature

9 Dec 2015

Abstract excerpt

Chloroquine is used clinically as an autophagy blocker to potentiate anticancer treatments. However, whether chloroquine acts solely through autophagy-dependent and cancer cell autonomous mechanisms has remained elusive. In a recent study we found that chloroquine reduced intratumoral hypoxia and metastasis, while improving chemotherapy response, largely through an autophagy-independent, NOTCH1-reliant mechanism...

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Share to Autophagy in Disease and Therapy
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27308577
DOI: 10.4161/23723548.2014.970097

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