Article
A proposed integrated approach for the preclinical evaluation of phage therapy in Pseudomonas infections.
Scientific reports - 15 Jun 2016
Danis-Wlodarczyk Katarzyna, Vandenheuvel Dieter, Jang Ho Bin, Briers Yves, Olszak Tomasz, Arabski Michal, Wasik Slawomir, Drabik Marcin, Higgins Gerard, Tyrrell Jean, Harvey Brian J, Noben Jean-Paul, Lavigne Rob, Drulis-Kawa Zuzanna
Abstract excerpt
Bacteriophage therapy is currently resurging as a potential complement/alternative to antibiotic treatment. However, preclinical evaluation lacks streamlined approaches. We here focus on preclinical approaches which have been implemented to assess bacteriophage efficacy against Pseudomonas biofilms and infections. Laser interferometry and profilometry were applied to measure biofilm matrix permeability and...
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