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Article

Spatial Colocalization of Human Ohnolog Pairs Acts to Maintain Dosage-Balance.

Molecular biology and evolution - 1 Sept 2016

Xie Ting, Yang Qing-Yong, Wang Xiao-Tao, McLysaght Aoife, Zhang Hong-Yu

Abstract excerpt

Ohnologs -paralogous gene pairs generated by whole genome duplication- are enriched for dosage sensitive genes, that is, genes that have a phenotype due to copy number changes. Dosage sensitive genes frequently occur in the same metabolic pathway and in physically interacting proteins. Accumulating evidence reveals that functionally related genes tend to co-localize in the three-dimensional (3D) arrangement of...

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Identifiers

PMID: 27297469
DOI: 10.1093/molbev/msw108
PMCID: PMC4989111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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