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Article

Relationship between CYP2B6*6 and cold pressor pain sensitivity in opioid dependent patients on methadone maintenance therapy (MMT).

Drug and alcohol dependence - 1 Aug 2016

Zahari Zalina, Lee Chee Siong, Ibrahim Muslih Abdulkarim, Musa Nurfadhlina, Mohd Yasin Mohd Azhar, Lee Yeong Yeh, Tan Soo Choon, Mohamad Nasir, Ismail Rusli

Abstract excerpt

BACKGROUND: CYP2B6 polymorphisms contribute to inter-individual variations in pharmacokinetics of methadone. Increased pain sensitivity is frequently reported by opioid dependent patients on methadone maintenance therapy (MMT). It is possible, therefore, that genetic polymorphisms in CYP2B6, which affects the metabolism of methadone, influence pain sensitivity among patients on MMT. This study investigated CYP2B6...

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Share to Analgesics, Opioid
Share to Cytochrome P-450 CYP2B6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Methadone

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Share to Pain Threshold

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 27289271
DOI: 10.1016/j.drugalcdep.2016.05.028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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