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Article

A computational analysis of the genetic and transcript diversity at the kallikrein locus.

Biological chemistry - 1 Dec 2016

Lai John, An Jiyuan, Srinivasan Srilakshmi, Clements Judith A, Batra Jyotsna

Abstract excerpt

The kallikrein related peptidase gene family (KLKs) comprises 15 genes located between 19q13.3-13.4. KLKs have chymotrypsin and/or trypsin like activity, but the tissue/organ expression profile of each KLK varies considerably. Thus, the role of KLKs in human biology is also very diverse, and the deregulation of their function results in a wide-range of diseases. Here, we have cataloged the transcript (variants...

Topics

Cluster Analysis
Genetic Loci
Genetic Variation
Genomics
Humans
Kallikreins
RNA, Messenger

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 27289002
DOI: 10.1515/hsz-2016-0161

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