Article
Genetic variants in glucose-6-phosphate isomerase gene as prognosis predictors in hepatocellular carcinoma.
Clinics and research in hepatology and gastroenterology - 1 Dec 2016
Lyu Zhuomin, Chen Yibing, Guo Xu, Zhou Feng, Yan Zhaoyong, Xing Jinliang, An Jiaze, Zhang Hongxin
Abstract excerpt
BACKGROUND: Metabolic reprogramming is an important hallmark of cancer cells, including the alterations of activity and expression of enzymes in glucose metabolism. Previous studies have demonstrated the critical role of glucise-6-phosphate isomerase (GPI) in cancer initiation, metastasis and progression. However, the significance of single nucleotide polymorphisms (SNPs) in GPI gene has not been investigated in...
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