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Article

Identification of genetic variants in pharmacokinetic genes associated with Ewing Sarcoma treatment outcome.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Sept 2016

Ruiz-Pinto S, Pita G, Patiño-García A, García-Miguel P, Alonso J, Pérez-Martínez A, Sastre A, Gómez-Mariano G, Lissat A, Scotlandi K, Serra M, Ladenstein R, Lapouble E, Pierron G, Kontny U, Picci P, Kovar H, Delattre O, González-Neira A

Abstract excerpt

BACKGROUND: Despite the effectiveness of current treatment protocols for Ewing sarcoma (ES), many patients still experience relapse, and survival following recurrence is <15%. We aimed to identify genetic variants that predict treatment outcome in children diagnosed with ES. PATIENTS AND METHODS: We carried out a pharmacogenetic study of 384 single-nucleotide polymorphisms (SNPs) in 24 key transport or metabolism...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to Cytochrome P-450 CYP2C8

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Multidrug Resistance-Associated Proteins

Share to Neoplasm Recurrence, Local

Share to Sarcoma, Ewing

Share to Survival Analysis

Share to Treatment Outcome

Source

Identifiers

PMID: 27287205
DOI: 10.1093/annonc/mdw234

Genes

ABCB1
ABCC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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