Article
miR-16 rescues F508del-CFTR function in native cystic fibrosis epithelial cells.
Gene therapy - 1 Nov 2015
Kumar P, Bhattacharyya S, Peters K W, Glover M L, Sen A, Cox R T, Kundu S, Caohuy H, Frizzell R A, Pollard H B, Biswas R
Abstract excerpt
Cystic fibrosis (CF) is due to mutations in the CFTR gene, which prevents correct folding, trafficking and function of the mutant cystic fibrosis transmembrane conductance regulator (CFTR) protein. The dysfunctional effect of CFTR mutations, principally the F508del-CFTR mutant, is further manifested by hypersecretion of the pro-inflammatory chemokine interleukin-8 into the airway lumen, which further contributes...
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