Article
The expression of Death Inducer-Obliterator (DIDO) variants in Myeloproliferative Neoplasms.
Blood cells, molecules & diseases - 1 Jul 2016
Berzoti-Coelho Maria Gabriela, Ferreira Aline Fernanda, de Souza Nunes Natalia, Pinto Mariana Tomazini, Júnior Maurício Cristiano Rocha, Simões Belinda Pinto, Martínez-A Carlos, Souto Elizabeth Xisto, Panepucci Rodrigo Alexandre, Covas Dimas Tadeu, Kashima Simone, Castro Fabíola Attié
Abstract excerpt
Chronic Myeloid Leukemia (CML), Polycythemia Vera (PV), Essential Thrombocythemia (ET) and Primary Myelofibrosis (PMF) are Myeloproliferative Neoplasms (MPN) characterized by clonal myeloproliferation without cell maturation impairment. CML pathogenesis is associated with the Ph chromosome leading to BCR-ABL tyrosine-kinase constitutive expression. The Ph negative MPN (PV, ET and PMF) are characterized by the...
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