Article
The Arabidopsis acetylated histone-binding protein BRAT1 forms a complex with BRP1 and prevents transcriptional silencing.
Nature communications - 7 Jun 2016
Zhang Cui-Jun, Hou Xiao-Mei, Tan Lian-Mei, Shao Chang-Rong, Huang Huan-Wei, Li Yong-Qiang, Li Lin, Cai Tao, Chen She, He Xin-Jian
Abstract excerpt
Transposable elements and other repetitive DNA sequences are usually subject to DNA methylation and transcriptional silencing. However, anti-silencing mechanisms that promote transcription in these regions are not well understood. Here, we describe an anti-silencing factor, Bromodomain and ATPase domain-containing protein 1 (BRAT1), which we identified by a genetic screen in Arabidopsis thaliana. BRAT1 interacts...
Topics
- Acetylation
- Arabidopsis
- Arabidopsis Proteins
- DNA Demethylation
- DNA Methylation
- Gene Silencing
- Genetic Loci
- Histones
- Models, Biological
- Mutation
- Protein Binding