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Article

Oxidative Stress and Polymorphism of Xenobiotic-Metabolizing Enzymes in Two Patients with Severe Alpha-1-Antitrypsin Deficiency.

Biochemical genetics - 1 Oct 2016

Topic Aleksandra, Nagorni-Obradovic Ljudmila, Francuski Djordje, Ljujic Mila, Malic Zivka, Radojkovic Dragica

Abstract excerpt

Alpha-1-antitrypsin deficiency (AATD) and tobacco smoke play a key role in the pathogenesis of early-onset emphysema. Differences in AATD-related chronic obstructive pulmonary disease stages imply the existence of modifying factors associated with disease severity. We present two male patients with emphysema caused by severe AATD (PiZZ genotype). Both are former smokers and have epoxide hydrolase low-activity...

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Identifiers

PMID: 27271084
DOI: 10.1007/s10528-016-9748-7

Genes

CRP
GSTP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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