Article
pSTAT3/pSTAT5 Signaling Patterns in Molecularly Defined Subsets of Myeloproliferative Neoplasms.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Feb 2018
Sakr Hany, Clark Schneider Kelli, Murugesan Gurunathan, Bodo Juraj, Hsi Eric D, Cook James R
Abstract excerpt
BCR/ABL1-negative myeloproliferative neoplasms (MPNs) are characterized by recurrent mutations in JAK2, CALR, and MPL, each of which has been reported to alter JAK/STAT signaling pathways. This report characterizes JAK/STAT signaling patterns in molecularly defined subsets of MPN utilizing immunohistochemistry for pSTAT3 and pSTAT5. Analysis of 30 BCR/ABL1-negative, nonpolycythemia vera MPN identified 15 (50%)...
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