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Article

Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers.

Cancer - 15 Sept 2016

Kothari Nishi, Teer Jamie K, Abbott Andrea M, Srikumar Thejal, Zhang Yonghong, Yoder Sean J, Brohl Andrew S, Kim Richard D, Reed Damon R, Shibata David

Abstract excerpt

BACKGROUND: The incidence and outcomes of patients with colorectal cancer (CRC) varies by age. Younger patients tend to have sporadic cancers that are not detected by screening and worse survival. To understand whether genetic differences exist between age cohorts, the authors sought to characterize unique genetic alterations in patients with CRC. METHODS: In total, 283 patients who were diagnosed with sporadic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27244218
DOI: 10.1002/cncr.30082
PMCID: PMC5014625

Genes

POLE
APC
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers.PMID 27244218Read ↗

Clinicopathological and mutational analyses of colorectal cancer with mutations in the POLE geneSemantic proximity Read ↗

Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study.Semantic proximity Read ↗

Germline RAD54L with somatic POLE defect implicated in Hypermutation phenotype: case report.Semantic proximity Read ↗

Colorectal cancer in patients of advanced age is associated with increased incidence of BRAF p.V600E mutation and mismatch repair deficiencySemantic proximity Read ↗

Exploring somatic mutations in POLE and POLD1: Their role in colorectal cancer pathogenesis and potential therapeutic strategiesSemantic proximity Read ↗

Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer.Semantic proximity Read ↗

Risk of colorectal cancer for carriers of a germ-line mutation in POLE or POLD1.Semantic proximity Read ↗

Genetic diagnosis of high-penetrance susceptibility for colorectal cancer (CRC) is achievable for a high proportion of familial CRC by exome sequencing.Semantic proximity Read ↗

Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancerSemantic proximity Read ↗

A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestine.Semantic proximity Read ↗

Genetic, structural, and functional characterization of POLE polymerase proofreading variants allows cancer risk prediction.Semantic proximity Read ↗

Age-Related Multigene Analysis of Colorectal Cancer Using Next-Generation SequencingSemantic proximity Read ↗

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