Article
Human ROBO1 regulates white matter structure in corpus callosum.
Brain structure & function - 1 Mar 2017
Darki Fahimeh, Massinen Satu, Salmela Elina, Matsson Hans, Peyrard-Janvid Myriam, Klingberg Torkel, Kere Juha
Abstract excerpt
The axon guidance receptor, Robo1, controls the pathfinding of callosal axons in mice. To determine whether the orthologous ROBO1 gene is involved in callosal development also in humans, we studied polymorphisms in the ROBO1 gene and variation in the white matter structure in the corpus callosum using both structural magnetic resonance imaging and diffusion tensor magnetic resonance imaging. We found that five...
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